Domenichino, real name Domenico Zampieri (1581-1641),
Italian painter, born in Bologna. He studied at the Carracci Academy in Bologna under the Italian painter Lodovico Carracci and in 1602 worked with Lodovico's cousin, the painter Annibale Carracci, on the fresco decoration in the gallery of the Farnese Palace in Rome.

Thereafter, Domenichino painted frescoes and panels for churches and palaces in Rome and Naples. His early work, such as the Last Communion of Saint Jerome (1614, Vatican, Rome), is classical in its calm, careful spatial organization. Later work, inspired by the Italian Renaissance artists Correggio and Michelangelo and marked by movement and dramatic foreshortening, is more baroque (see Baroque Art and Architecture).

Examples include his frescoes for the San Gennaro Chapel (1631-1634, 1635-1641) in Naples Cathedral. Domenichino's classical landscapes influenced those of the French artist Claude Lorrain.